2000 - 2004 Bachelor, South China Agricultural University

2004 - 2007 Master, South China University of Technology

2008 - 2009 Exchange Ph.D.student, National Cancer Centre Singapore

2007 - 2011 Ph.D., Sun Yat-sen University

2011 - 2016 Postdoctoral fellow, The University of Texas MD Anderson Cancer Center

2016 - 2019 Instructor, The University of Texas MD Anderson Cancer Center

2019 - Professor, Institute of Biophysics, Chinese Academy of Sciences

2018 USCACA&AFCR Scholar Awards

2016 Caroline Ross Endowed Fellowship, The University of Texas MD Anderson Cancer Center

2016 The Harold C. and Mary L. Daily Endowment Fund Fellowship, The University of Texas MD Anderson Cancer Center

2015 The Anne Eastland Spears Fellowship in GI Cancer Research, The University of Texas MD Anderson Cancer Center

2013 - 2016 Odyssey Fellow,The University of Texas MD Anderson Cancer Center

1. Uncover the metabolic vulnerabilities in oncogene-driven cancers.

2. Identify the immunomodulatory metabolic enzymes and metabolites.

(# First author, * corresponding author)

1. Sun PK^#, Zhang ZX^#, Wang B, Liu CY, Chen C, Liu P,Li XJ*. A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages.Nature Communications2022; 13(1): 6562

2. Chen C^#, Zhang ZX^#, Liu CY, Wang B, Liu P, Fang S, Yang F, You YP,Li XJ*. ATF4-dependent fructolysis fuels growth of glioblastoma multiforme.Nature Communications2022; 13(1): 6108

3. Zhang ZX^#, Chen C^#, Yang F, Zeng YX, Sun PK, Liu P,Li XJ*. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.Molecular Cell2022; 82(15): 2844-2857

4. Zhang ZX^#, Li X^#, Yang F^#, Chen C^#, Liu P, Ren Y, Sun PK, Wang ZX, You YP, Zeng YX,Li XJ*. DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis.Nature Communications2021; 12(1): 5872

5.Li XJ^#*, Qian X^#, Wang B, Xia Y, Zheng YH, Du LY, Xu DQ, Xing DM, DePinho RA, and Lu Z*. Programmable Base Editing of Mutated TERT Promoter Inhibits Brain Tumor Growth.Nature Cell Biology2020; 22 (3): 282-288 (Highlighted News & Views ofNature Cell Biology)

6. Qian X^#*,Li XJ^#, Shi ZM, Bai XM, Xia Y, Zheng YH, Xu DQ, Chen F, You YP, Fang J, Hu ZB, Zhou Q, Lu Z*. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis.Molecular Cell2019; 76(6): 885-895

7. Qian X^#*,Li XJ^#, Shi ZM, Xia Y, Cai QS, Xu DQ, Tan L, Du LY, Zheng YH, Zhao D, Zhang CB, Lorenzi PL, You YP, Jiang BH, Jiang T, Li HT, Lu Z*. PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1.Molecular Cell2019; 76(3): 516-527

8.Li XJ^#, Qian X^#, Jiang HF, Xia Y, Zheng YH, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, and Lu Z*. Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication.Molecular Cell2018; 72(4): 650-660

9.Li XJ^#, Egervari G^#, Wang YG, Berger SL*, and Lu Z*. Regulation of chromatin and gene expression by metabolic enzymes and metabolites.Nature Reviews Molecular Cell Biology2018; 19(9): 563-578 (Cover story)　　

10. Qian X^#,Li XJ^#, Tan L, Lee JH, Xia Y, Cai QS, Zheng YH, Wang HX, Lorenzi PL, and Lu Z*. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress.Cancer Discovery2018; 8 (1): 94-107　　

11.Li XJ, Yu W, Qian X, Xia Y, Zheng YH, Lee JH, Li W, Lyu JX, Rao G, Zhang XC, Qian CN, Rozen SG, Jiang T, and Lu Z*. Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy.Molecular Cell2017; 66 (5): 684-697 (Research Highlight ofNature Reviews Molecular Cell Biology)　　

12.Li XJ, Qian X, Peng LX, Jiang YH, Hawke D, Zheng YH, Xia Y, Lee JH, Cote G, Wang HX, Wang LW, Qian CN, and Lu Z*. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.Nature Cell Biology2016; 18 (5): 561-571(Research Highlight ofScience Signaling)　　

13.Li XJ, Jiang YH, Meisenhelder J, Yang WW, Hawke D, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang LW, and Lu Z*. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.Molecular Cell2016; 61 (5): 705-719　　

14.Li XJ, Peng LX, Shao JY, Lu WH, Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, Zheng FJ,Zeng MS, Kang TB, Zeng YX, Teh BT, Qian CN*. As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling.Carcinogenesis2012; 33 (7): 1302-1309　

15.Li XJ, Ong CK, Cao Y, Xiang YQ, Shao JY, Ooi A, Peng LX, Lu WH, Zhang Z, Petillo D, Qin L, Bao YN, Zheng FJ, Chia CS, Iyer NG, Kang TB, Zeng YX, Soo KC, Trent JM, Teh BT, Qian CN*. Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis.Cancer Research2011;71 (8):3162-3172

(From Xinjian Li, November 7, 2022)