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中国科学院感染与免疫重点实验室

李新建博士研究员博士生导师

中科院生物物理所，中科院感染与免疫重点实验室，研究组长

研究方向：肿瘤进展与天然免疫反应过程中的代谢重编程

电子邮件：lixinjian@ibp.ac.cn

电话：010-64888557

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/en_sourcedb_ibp/rck/EN_xsszmL/202005/t20200519_341398.html

简历：

　　2000 - 2004 华南农业大学，学士

　　2004 - 2007 华南理工大学，硕士

　　2008 - 2009 新加坡国立癌症研究中心，联合培养博士生

　　2007 - 2011 中山大学，博士

　　2011 - 2016 美国MD安德森癌症中心，博士后

　　2016 - 2019 美国MD安德森癌症中心，讲师

　　2019 - 至今中国科学院生物物理研究所，研究员

获奖及荣誉：

　　2018　美中抗癌协会和美国亚洲癌症研究基金会（USCACA-AFCR）奖学金

　　2016　MD安德森癌症中心Caroline Ross Endowed Fellowship

　　2016　MD安德森癌症中心The Harold C. and Mary L. Daily Endowment Fund Fellowship

　　2015　MD安德森癌症中心The Anne Eastland Spears Fellowship

　　2013　MD安德森癌症中心Odyssey Fellowship

社会任职：

研究方向：

1. 揭示癌基因驱动的恶性肿瘤的代谢弱点。

2. 鉴定具有免疫调节功能的代谢酶以及代谢产物。

承担项目情况：

代表论著：

(# First author, * corresponding author)

1. Sun PK^#, Zhang ZX^#, Wang B, Liu CY, Chen C, Liu P,Li XJ*. A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages.Nature Communications2022; 13(1): 6562

2. Chen C^#, Zhang ZX^#, Liu CY, Wang B, Liu P, Fang S, Yang F, You YP,Li XJ*. ATF4-dependent fructolysis fuels growth of glioblastoma multiforme.Nature Communications2022; 13(1): 6108

3. Zhang ZX^#, Chen C^#, Yang F, Zeng YX, Sun PK, Liu P,Li XJ*. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.Molecular Cell2022; 82(15): 2844-2857

4. Zhang ZX^#, Li X^#, Yang F^#, Chen C^#, Liu P, Ren Y, Sun PK, Wang ZX, You YP, Zeng YX,Li XJ*. DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis.Nature Communications2021; 12(1): 5872

5.Li XJ^#*, Qian X^#, Wang B, Xia Y, Zheng YH, Du LY, Xu DQ, Xing DM, DePinho RA, and Lu Z*. Programmable Base Editing of Mutated TERT Promoter Inhibits Brain Tumor Growth.Nature Cell Biology2020; 22 (3): 282-288 (Highlighted News & Views ofNature Cell Biology)

6. Qian X^#*,Li XJ^#, Shi ZM, Bai XM, Xia Y, Zheng YH, Xu DQ, Chen F, You YP, Fang J, Hu ZB, Zhou Q, Lu Z*. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis.Molecular Cell2019; 76(6): 885-895

7. Qian X^#*,Li XJ^#, Shi ZM, Xia Y, Cai QS, Xu DQ, Tan L, Du LY, Zheng YH, Zhao D, Zhang CB, Lorenzi PL, You YP, Jiang BH, Jiang T, Li HT, Lu Z*. PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1.Molecular Cell2019; 76(3): 516-527

8.Li XJ^#, Qian X^#, Jiang HF, Xia Y, Zheng YH, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, and Lu Z*. Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication.Molecular Cell2018; 72(4): 650-660

9.Li XJ^#, Egervari G^#, Wang YG, Berger SL*, and Lu Z*. Regulation of chromatin and gene expression by metabolic enzymes and metabolites.Nature Reviews Molecular Cell Biology2018; 19(9): 563-578 (Cover story)　　

10. Qian X^#,Li XJ^#, Tan L, Lee JH, Xia Y, Cai QS, Zheng YH, Wang HX, Lorenzi PL, and Lu Z*. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress.Cancer Discovery2018; 8 (1): 94-107　　

11.Li XJ, Yu W, Qian X, Xia Y, Zheng YH, Lee JH, Li W, Lyu JX, Rao G, Zhang XC, Qian CN, Rozen SG, Jiang T, and Lu Z*. Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy.Molecular Cell2017; 66 (5): 684-697 (Research Highlight ofNature Reviews Molecular Cell Biology)　　

12.Li XJ, Qian X, Peng LX, Jiang YH, Hawke D, Zheng YH, Xia Y, Lee JH, Cote G, Wang HX, Wang LW, Qian CN, and Lu Z*. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.Nature Cell Biology2016; 18 (5): 561-571(Research Highlight ofScience Signaling)　　

13.Li XJ, Jiang YH, Meisenhelder J, Yang WW, Hawke D, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang LW, and Lu Z*. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.Molecular Cell2016; 61 (5): 705-719　　

14.Li XJ, Peng LX, Shao JY, Lu WH, Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, Zheng FJ,Zeng MS, Kang TB, Zeng YX, Teh BT, Qian CN*. As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling. Carcinogenesis2012; 33 (7): 1302-1309　

15.Li XJ, Ong CK, Cao Y, Xiang YQ, Shao JY, Ooi A, Peng LX, Lu WH, Zhang Z, Petillo D, Qin L, Bao YN, Zheng FJ, Chia CS, Iyer NG, Kang TB, Zeng YX, Soo KC, Trent JM, Teh BT, Qian CN*. Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis.Cancer Research2011;71 (8):3162-3172

（资料来源：李新建研究员，2022-11-07）