Recent positive selection signatures reveal phenotypic evolution in the Han Chinese population
Huaxia Luo, Peng Zhang, Wanyu Zhang, Yu Zheng, Di Hao, Yirong Shi, Yiwei Niu, Tingrui Song, Yanyan Li, Shilei Zhao, Hua Chen, Tao Xu, Shunmin He
Abstract
Characterizing natural selection signatures and relationships with phenotype spectra is important for understanding human evolution and both biological and pathological mechanisms. Here, we identified 24 genetic loci under recent selection by analyzing rare singletons in 3946 high-depth whole-genome sequencing data of Han Chinese. The loci include immune-related gene regions (MHCcluster,IGHcluster,STING1,PSG), alcohol metabolism-related gene regions (ADH1B,ALDH2,ALDH3B2), and the olfactory perception geneOR4C16, in which theMHCcluster,ADH1BandALDH2were also identified by TOPMed and WestLake Biobank. Among the signals, the IGH cluster is particularly interesting, in which the favored allele of variant 14_105737776_C_T (rs117518546, IgG1-G396R) promotes immune response, but also increases the risk of an autoimmune disease systemic lupus erythematosus (SLE). It is also surprising that our newly discoveredALDH3B2evolved in the opposite direction toALDH2for alcohol metabolism. Besides monogenic traits, we found that multiple complex traits experienced polygenic adaptation. Particularly, multi-methods consistently revealed that lower blood pressure was favored in natural selection. Finally, we built a database named RePoS (Recent Positive Selection,http://bigdata.ibp.ac.cn/RePoS/) to integrate and display multi-population selection signals. Our study extended our understanding of natural evolution and phenotype adaptation in Han Chinese as well as other populations.
附件下载：
Recent positive selection signatures reveal phenotypic evolution in the Han Chinese population,Sci Bull, 10 Aug 2023
Science Bulletin, 10 August, 2023, DOI：https://doi.org/10.1016/j.scib.2023.08.027
Recent positive selection signatures reveal phenotypic evolution in the Han Chinese population
Huaxia Luo, Peng Zhang, Wanyu Zhang, Yu Zheng, Di Hao, Yirong Shi, Yiwei Niu, Tingrui Song, Yanyan Li, Shilei Zhao, Hua Chen, Tao Xu, Shunmin He
Abstract
Characterizing natural selection signatures and relationships with phenotype spectra is important for understanding human evolution and both biological and pathological mechanisms. Here, we identified 24 genetic loci under recent selection by analyzing rare singletons in 3946 high-depth whole-genome sequencing data of Han Chinese. The loci include immune-related gene regions (MHCcluster,IGHcluster,STING1,PSG), alcohol metabolism-related gene regions (ADH1B,ALDH2,ALDH3B2), and the olfactory perception geneOR4C16, in which theMHCcluster,ADH1BandALDH2were also identified by TOPMed and WestLake Biobank. Among the signals, the IGH cluster is particularly interesting, in which the favored allele of variant 14_105737776_C_T (rs117518546, IgG1-G396R) promotes immune response, but also increases the risk of an autoimmune disease systemic lupus erythematosus (SLE). It is also surprising that our newly discoveredALDH3B2evolved in the opposite direction toALDH2for alcohol metabolism. Besides monogenic traits, we found that multiple complex traits experienced polygenic adaptation. Particularly, multi-methods consistently revealed that lower blood pressure was favored in natural selection. Finally, we built a database named RePoS (Recent Positive Selection,http://bigdata.ibp.ac.cn/RePoS/) to integrate and display multi-population selection signals. Our study extended our understanding of natural evolution and phenotype adaptation in Han Chinese as well as other populations.
文章链接：https://www.sciencedirect.com/science/article/pii/S2095927323005558
相关报道：//www.wyreworks.com/kyjz/zxdt/202308/t20230828_6867851.html