杰出青年科学基金获得者

　　1986 - 1990    南开大学，理学学士学位

　　1990 - 1993    北京师范大学，理学硕士学位

　　1993 - 1996    北京大学，理学博士学位

　　1996 - 1998    中国科学院生物物理研究所，助理研究员

　　1998 - 2000 中国科学院生物物理研究所副研究员，获得英国皇家学会K. C. Wong Fellowship，受英国皇家学会Joint project资助，在英国国立食品研究所（Institute of Food Research,　UK）做访问学者。

　　2000 - 至今    中国科学院生物物理研究所创新研究课题组长(PI)，2004年晋升研究员

　　2004.12-2005.3 英国剑桥MRC（Medical Research Council），访问学者

　　2015 - 至今    生物大分子与科教融合卓越中心，研究员

　　2015 - 至今    中国科学院大学，岗位教授

　　2018.3 - 2018.8  美国国立卫生研究院 （NIH）国家神经疾病和中风研究所访问学者

　　2015 获中华人民共和国国务院“政府特殊津贴”

　　2014 中国科学院京区“巾帼建功”先进个人

　　2012 获国家杰出青年科学基金

　　2006 获第13届国际自由基大会青年研究者奖(亚洲)

　　生命离不开氧，细胞的氧化还原状态直接调控蛋白质等大分子功能，氧化还原应激是细胞信号转导和效应的重要调控方式，介导衰老、神经退行性疾病、代谢病、肿瘤等许多生理和病理过程。陈畅课题组长期致力于系统揭示细胞内氧化还原生物活性小分子的产生和代谢，发现氧化还原调控的新基因，结合光遗传学技术及自主构建的特异氧化还原探针和超高分辨成像技术，“绘制”细胞内不同细胞器內源氧化还原状态全景图谱（Redox Map），阐述氧化还原活性小分子与生物大分子的cross talk，研究氧化还原调控与衰老及相关疾病的关系以及天然产物和中医药（如：枸杞）的有效调控及中医药现代化理论。主要研究方向包括：氧化还原调控，衰老，中医药理论和作用机制（traditional Chinese medicine, TCM）。具体包括：细胞氧化还原调控与衰老及相关疾病；一氧化氮与蛋白质巯基亚硝基化修饰(S-nitros(yl)ation)及其它巯基修饰和细胞质量控制；缺氧与疾病及调控（肿瘤、代谢疾病、心脑血管疾病等），重点开展S-nitrosoglutathione reductase (GSNOR) 和 phosphatidylinositol 4-kinase type IIα (PI4KIIα) 的功能、机制和转化应用研究。

1. Meng J^#, Lv Z^#, Chen X^#, Sun C, Jin C, Ding K*,Chen C*. LBP1C-2 from Lycium barbarum maintains skeletal muscle satellite cell pool by interaction with FGFR1.iScience. 2023, 106573.

2. Zhang H^#, Yu F^#, Xie P^#, Sun S^#, Qiao X^#, Tang S,Chen C, Yang S, Mei C, Yang D, Wu Y, Xia R, Li X, Lu J, Liu Y, Xie X, Ma D, Xu X, Liang Z, Feng Z, Huang X, Yu H, Liu G, Wang Y, Li J, Zhang Q, Chen C, Ouyang Y, Xie Q*. A Gγ protein regulates alkaline sensitivity in crops.Science. 2023 Mar 24;379(6638):eade8416.

3. Sun C^#, Chen X^#, Yang S, Jin C, Ding K*,Chen C*. LBP1C-2 from Lycium barbarum alleviated age-related bone loss by targeting BMPRA/BMPRII/Noggin.Carbohyd Polym. 2023, 310: 120725.

4. Zhang W, Qiao X，Xie T, Cai W, Zhang X,Chen C*, Zhang Y. Multi-Omics Approach Reveals Redox Homeostasis Reprogramming in Early-Stage Clear Cell Renal Cell Carcinoma.Antioxidants. 2023, 12, 81.

5. Gao L^#, Qiao X^#, Zhang L, Wang Y, Wan Y*,Chen C*. Nitric oxide inhibits alginate biosynthesis in Pseudomonas aeruginosa and increases its sensitivity to tobramycin by downregulating algU gene expression.Nitric Oxide. 2022 Aug 17:S1089-8603(22)00084-2.

6.陈畅*. 精准氧化还原调控.药学学报. 2022, 57(6): 1541-1543.

7. Zhang Y^#, Qiao X^#,*, Liu L^#, Han W, Liu Q, Wang Y, Xie T, Tang Y, Wang T, Meng J, Ye A, He S, Chen R*,Chen C*. Long noncoding RNA MAGI2-AS3 regulates the H₂O₂level and cell senescence via HSPA8.Redox Biol. 2022 Aug;54:102383.

8. Wang Y^#, Qiao X^#, Shi C^#, Ye A^#, Guo M, Zhao Y*,Chen C*. Exercise Alleviates ER Reductive Stress and Promotes Healthy Aging[J].Prog Biochem Biophys. 2022, 49(3): 444-453.

9. Meng J^#, Lv Z^#, Guo M, Sun C, Li X, Jiang Z, Zhang W,Chen C*. ALycium barbarumextract inhibits β-amyloid toxicity by activating the antioxidant system and mtUPR in a Caenorhabditis elegans model of Alzheimer's disease.FASEB J. 2022 Feb;36(2):e22156.

10. Qiao X, Zhang Y, Ye A, Zhang Y, Xie T, Lv Z, Shi C, Wu D, Chu B, Wu X, Zhang W, Wang P, Liu GH, Wang CC, Wang L*,Chen C*. ER reductive stress caused by Ero1α S-nitrosation accelerates senescence.Free Radic Biol Med. 2022 Feb 20;180:165-178.

11. Xie T^#, Qiao X^#, Sun C^#, Chu B, Meng J,Chen C*. GAPDH S-nitrosation contributes to age-related sarcopenia through mediating apoptosis.Nitric Oxide. 2021 Dec 29;120:1-8.

12. Meng J, Lv Z, Wang Y,Chen C*. Identification of the redox-stress signaling threshold (RST): Increased RST helps to delay aging inC. elegans.Free Radic Biol Med. 2021 Nov 27;178:54-58.

13. Cai WB, Zhao YJ, Liu L, Cheng Q, Wang J, Shi XL, Yao L, Qiao XH, Zhu Y,Chen C*, Zhang X*. Redox environment metabolomic evaluation (REME) of the heart after myocardial ischemia/reperfusion injury.Free Radic Biol Med. 2021 Jul 9;173:7-18.

14. Yi W^#, Zhang Y^#, Liu B^#,*, Zhou Y, Liao D, Qiao X, Gao D, Xie T, Yao Q, Zhang Y, Qiu Y, Huang G, Chen Z*,Chen C*, Ju Z*. Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration.Cell Rep. 2021 Mar 30;34(13):108922.

15. Meng J, Lv Z, Zhang Y, Wang Y, Qiao X, Sun C, Chen Y, Guo M, Han W, Ye A, Xie T, Chu B, Shi C, Yang S,Chen C*. Precision Redox: The Key for Antioxidant Pharmacology.Antioxid Redox Signal. 2021 May 10;34(14):1069-1082.

16. Meng J^#, Lv Z^#, Sun C, Qiao X,Chen C*. An extract of Lycium barbarum mimics exercise to improve muscle endurance through increasing type IIa oxidative muscle fibers by activating ERRγ.FASEB J. 2020 Sep;34(9):11460-11473.

17. Yang J^#, Zhang H^#, Gong W^#, Liu Z, Wu H, Hu W, Chen X, Wang L, Wu S,Chen C*, Perrett S*. S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid.J Biol Chem. 2020 Jun 12;295(24):8302-8324.

18. Zheng WQ^#, Zhang Y^#, Yao Q^#, Chen Y^#, Qiao X, Wang ED*,Chen C*, Zhou XL*. Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation.Nucleic Acids Res. 2020 Jul 9;48(12):6799-6810.

19. Ban Y^#, Liu Y^#, Li Y, Zhang Y, Xiao L, Gu Y, Chen S, Zhao B,Chen C*, Wang N*. S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension.Redox Biol. 2019 Feb;21:101099.

20. Li J, Zhang Y, Zhang Y, Lü S, Miao Y, Yang J, Huang S, Ma X, Han L, Deng J, Fan F, Liu B, Huo Y, Xu Q,Chen C*, Wang X*, Feng J*. GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation.Redox Biol. 2018 Jul;17:386-399.

21. Li J, Gao Z, Zhao D, Zhang L, Qiao X, Zhao Y, Ding H, Zhang P, Lu J, Liu J, Jiang H, Luo C*,Chen C*. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells.Cancer Res. 2017 Nov 15;77(22):6253-6266.

22. Zhang Y, Wu K, Su W, Zhang DF, Wang P, Qiao X, Yao Q, Yuan Z, Yao YG, Liu G, Zhang C, Liu L,Chen C*. Increased GSNOR Expression during Aging Impairs Cognitive Function and Decreases S-Nitrosation of CaMKIIα.J Neurosci. 2017 Oct 4;37(40):9741-9758.

23. Li Y, Zhang Y, Wang L, Wang P, Xue Y, Li X, Qiao X, Zhang X, Xu T, Liu G, Li P,Chen C*. Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia.Autophagy. 2017 Jul 3;13(7):1145-1160.

24. Ding Y^#, Li Y^#, Zhang X, He J, Lu D, Fang X, Wang Y, Wang J, Zhang Y, Qiao X, Gan LM,Chen C*, Zhu Y*. Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia-reperfusion injury.J Mol Cell Cardiol. 2017 Sep;110:70-79.

25. Meng J, Lv Z, Qiao X, Li X, Li Y, Zhang Y,Chen C*. The decay of Redox-stress Response Capacity is a substantive characteristic of aging: Revising the redox theory of aging.Redox Biol. 2017 Apr;11:365-374.

26. Zhang H, Yang J, Wu S, Gong W,Chen C*, Perrett S*. Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response.J Biol Chem. 2016 Mar 25;291(13):6967-81.

27. Gao L^#, Zhang Y^#, Wang Y, Qiao X, Zi J,Chen C*, Wan Y*. Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa.Redox Biol. 2016 Aug;8:252-8.

28. Yin R, Fang L, Li Y, Xue P, Li Y, Guan Y, Chang Y,Chen C*, Wang N*. Pro-inflammatory Macrophages suppress PPARγ activity in Adipocytes via S-nitrosylation.Free Radic Biol Med. 2015 Dec;89:895-905.

29. Qiao, X, HU, M, Zhang, Y, Li Y,Chen, C*. Cellular redox regulation and thiol modification.Chinese Bulletin of Life Sciences. 2015 27(3), 374-382.

30. Zhou Q^#, Li J^#, Yu H, Zhai Y, Gao Z, Liu Y, Pang X, Zhang L, Schulten K*, Sun F*,Chen C*. Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα.Nat Commun. 2014 Mar 28;5:3552.

31. Li J, Zhang L, Gao Z, Kang H, Rong G, Zhang X,Chen C*. Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-tumor strategy.Protein Cell. 2014 Jun;5(6):457-68.

32. Sun F, Li J,Chen C*. Puzzle out the regulation mechanism of PI4KIIα activity.Sci China Life Sci. 2014 Jun;57(6):636-8.

33. Wu K^#, Ren R^#, Su W^#, Wen B, Zhang Y, Yi F, Qiao X, Yuan T, Wang J, Liu L, Izpisua Belmonte JC*, Liu GH*,Chen C*. A novel suppressive effect of alcohol dehydrogenase 5 in neuronal differentiation.J Biol Chem. 2014 Jul 18;289(29):20193-9.

34. Wu K, Zhang Y, Wang P, Zhang L, Wang T,Chen C*. Activation of GSNOR transcription by NF-κB negatively regulates NGF-induced PC12 differentiation.Free Radic Res. 2014 Sep;48(9):1011-7.

35. Hu M, Xu T*,Chen C*. Evaluation of the mitochondrial redox status inCaenorhabditis elegans: an assay based on the COPAS biosort flow cytometer.Acta Biophys Sin. 2014 30(2), 110-116.

36. Mao K^#, Chen S^#, Chen M, Ma Y, Wang Y, Huang B, He Z, Zeng Y, Hu Y, Sun S, Li J, Wu X, Wang X, Strober W,Chen C*, Meng G*, Sun B*. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.Cell Res. 2013 Feb;23(2):201-12.

37. Zhang X^#, Huang B^#, Zhang L, Zhang Y, Zhao Y, Guo X, Qiao X,Chen C*. SNObase, a database for S-nitrosation modification.Protein Cell. 2012 Dec;3(12):929-33.

38. Zhang X^#, Huang B^#,Chen C*. SNO spectral counting (SNOSC), a label-free proteomic method for quantification of changes in levels of protein S-nitrosation.Free Radic Res. 2012 Aug;46(8):1044-50.

39. Huang B,Chen C*. Function and Mechanism of Nitric Oxide (I)-Characteristics and Function.Acta Biophys Sin. 2012 28(3), 173-184.

40. Huang B,Chen C*.  Function and Mechanism of Nitric Oxide (II)-Mechanism and Protein S-Nitrosation.Acta Biophys Sin. 2012 28(4), 268-277.

41. Hou Q^#, Jiang H^#, Zhang X, Guo C, Huang B, Wang P, Wang T, Wu K, Li J, Gong Z, Du L, Liu Y, Liu L*,Chen C*. Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila.Nitric Oxide. 2011 Jan 1;24(1):17-24.

42. Zhang X^#, Huang B^#, Zhou X,Chen C*. Quantitative proteomic analysis of S-nitrosated proteins in diabetic mouse liver with ICAT switch method.Protein Cell. 2010 Jul;1(7):675-87.

43. Huang B,Chen C*. Detection of protein S-nitrosation using irreversible biotinylation procedures (IBP).Free Radic Biol Med. 2010 Aug 1;49(3):447-56.

44. Zhou X, Han P, Li J, Zhang X, Huang B, Ruan HQ,Chen C*. ESNOQ, proteomic quantification of endogenous S-nitrosation.PLoS One. 2010 Apr 2;5(4):e10015.

45. Li J, Lu Y, Zhang J, Kang H, Qin Z*,Chen C*. PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation.Oncogene. 2010 Apr 29;29(17):2550-9.

专      利：

1.Chang Chen, Kan Ding, Xingke Yang, Chuanxin Sun, Xia Chen, Can Jin，LBP1C-2, a homogenous polysaccharide from Lycium barbarum, methods of using in age-related bone loss. Patent Application No. 63/389,082.

2.Chang Chen, Jiao Meng, Zhenyu Lv, Chuanxin Sun, Xinhua Qiao, LYCIUM BARBARUM EXTRACTS, RESULTING COMPOSITIONS, METHODS OF MAKING AND METHODS OF USING THE SAME. Patent Application No. 42021042963.5 （香港）

3.Chang Chen, Kan Ding, Xingke Yang, Jiao Meng, Can Jin, Zhenyu Lv, Chuanxin Sun, Xia Chen. COMPOSITION COMPRISING HOMOGENEOUS POLYSACCHARIDE AND METHOD OF USING THE SAME TO IMPROVE MUSCLE SATELLITE CELLS. Patent Application No. 63/344,158.

4.Chang Chen, Yang Ye, Xingke Yang, Kaixian Chen, Xiaomin Luo, Jiao Meng, Sheng Yao, Zhenyu Lv. COMPOSITION COMPRISING NARINGENIN OR DERIVATIVE THEREOF, METHOD OF MAKING AND METHOD OF USING THE SAME. Patent Application No. 63/323,146.

5.陈畅；孟姣；吕振宇；孙传鑫；乔新华，含枸杞提取物的组合物及其制备方法和应用方法，ZL202110023756.8 授权日期：2022-01-08

6.Chang Chen, Jiao Meng, Zhenyu Lv, Chuanxin Sun, Xinhua Qiao, Lycium barbarum extracts, resulting compositions, methods of making and methods of using the same. Patent No. US11,135,260 B2, Date of Patent: 2021-10-05.

7. 仝小林；陈畅，一种抗抑郁的药物组合物和制备方法及其用途， ZL201811628807.4，授权日期：2021-12-17。

8. 仝小林；陈畅，一种治疗糖尿病的药物组合物和制备方法及其用途，ZL 201811626580.X，授权日期：2021-10-22，授权公告号：CN111375020B。

9.陈畅、罗成、蒋华良、李江美、高振、赵丹、张伦峰、乔新华，肌醇磷脂4位激酶二型α亚型特异抑制剂PI-273的应用，ZL 201510831539.6, 授权日期：2021-1-29

10. Yi Wan,Chang Chen, Lei Gao, Yuying Zhang, Xinhua Qiao, Yan Wang, Method, target and application for NO accumulation to decrease Pseudomonas aeruginosa invasiveness，US 10537593B2, United States，授权日期：2020-01-21

11. 万一；陈畅；高振；张玉英；乔新华；王琰，NO累计降低铜绿假单胞菌侵袭力的方法、靶点及应用，ZL 201510697439.9，授权日期：2019-5-17

12.陈畅、黄波，特异检测蛋白质或多肽半胱氨酸巯基修饰的方法及其用途，ZL200910084155.7，授权日期：2013-08-28，授权公告号：CN101893634B。

13.陈畅、李江美，肌醇磷脂4位激酶二型α亚型 PI4KIIα的应用，ZL200810104272.0，授权日期：2013-05-08，授权公告号：CN101560546B。

论著章节：

1.Chang Chen,Free Radical Biology. Encyclopedia of China, 2017.

2.Chang　Chen,　H.　R.　Tang,　and　P.　Belton.　Natural　antioxidants　-　an　ESR　perspective,　in　"Magnetic　Resonance　in　Food　Science”,　Ed.　G.A.　Webb,　The　Royal　Society　of　Chemistry　publishing,　UK.　2000.

3.陈畅，“一氧化氮功能及其作用机制”，《自由基生物医学》第七章，主编：郑荣梁、赵崇义、魏耀挥、黄中洋，艺轩图书出版社，台湾，2013，ISBN　978-957-616-983-0.

（资料来源：陈畅研究员，2023-04-19）