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创新研究群体项目获得者

高利增博士研究员博士生导师

中国生物物理学会理事 入选海外高层次人才计划青年项目 中国生物物理学会纳米酶分会副会长 中科院生物物理所，蛋白质与多肽药物所重点实验室，中国科学院纳米酶工程实验室，研究组长

研究方向：纳米酶工程与微生物防治，纳米生物医学工程

电子邮件：gaolizeng@ibp.ac.cn

电话：010-64888534

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/en_sourcedb_ibp/rck/EN_xsszmA_G/202005/t20200519_341413.html

简历：

　　1996.09 - 2000.07 吉林大学，生物化学，理学学士

　　2000.09 - 2003.07 吉林大学，生物化学，理学硕士

　　2003.09 - 2006.07 中国科学院生物物理研究所，生物化学与分子生物学，理学博士

　　2006.09 - 2010.01 美国匹兹堡大学，石油与化学工程系，博士后

　　2010.01 - 2013.11 美国康奈尔大学，Baker Institute for Animal Health, 博士后

　　2013.12 - 2015.07 美国宾夕法尼亚大学，School of Dental Medicine, 博士后

　　2015.08 - 2019.08 扬州大学，医学院/转化医学研究院，江苏特聘教授

　　2019.09 - 至今中国科学院生物物理研究所，纳米酶工程实验室，研究员/研究组长

获奖及荣誉：

　　2015年国际牙医协会口腔护理创新奖

　　2010年北京市科学技术奖一等奖（第二）

社会任职：

研究方向：

　　纳米酶新材料的的设计与合成，以铁基纳米材料为核心，模拟含铁天然酶的催化活性中心，开发具有高活性、高稳定性的人工模拟酶；以纳米酶为基础建立了多种抗菌抗感染新策略。

　　1. 首次报道了四氧化三铁具有类过氧化物酶催化活性，是一种新型的模拟酶，为纳米酶的发展奠基了基础；仿照天然酶活性中心结构理性设计纳米酶，提高其催化活性接近或超越天然酶。

　　2. 建立纳米酶清除生物膜耐药菌和抑制胞内菌的方法并阐明了相关机制，提出了人工模拟免疫系统防御细菌等病原微生物的概念与方法；纳米酶具有杀菌特异性和选择性。

　　3. 发现细菌铁死亡现象，纳米酶诱导细菌发生脂质过氧化，并且巨噬细胞抑制胞内菌也是通过调控铁死亡，表明细菌铁死亡是一种新的杀菌机制；并这一机制拓展到灭活病毒和增强疫苗免疫效果。

　　4. 推动纳米酶转化应用，在口腔龋病、细菌性阴道炎防治方面开展临床相关研究，并进行产业转化。

承担项目情况：

代表论著：

1. Ruonan Ma, Ling Fang, Lei Chen, Xiaonan Wang, Jing Jiang,Lizeng Gao*. Ferroptotic stress promotes macrophages against intracellular bacteria.Theranostics, 2022, 12(5): 2266-2289.

2. Caiyu Zhou, Qian Wang, Jing Jiang,Lizeng Gao*.Antibiotics, 2022, 11 (3): 390.

3. Juqun Xi, Yanqiu Wang, Xuejiao Gao, Yaling Huang, Jie Chen, Yong Chen, Lei Fan,Lizeng Gao*. Reverse intratumor bacteria-induced gemcitabine resistance with carbon nanozymes for enhanced tumor catalytic-chemo therapy.Nano Today, 2022, 43: 101395.

4. Jing Pang, Xu Feng, Qian Liang, Xiaoyan Zheng, Yiman Duan, Xin Zhang, Jubiao Zhang, Yang Chen, Kelong Fan*,Lizeng Gao*, Juxue Li*. Ferritin-Nanocaged ATP Traverses the Blood-Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model.ACS Nano, 2022, 16 (3), 4175-4185.

5. Ling Fang, Ruonan Ma, Xuejiao J Gao, Lei Chen, Yuan Liu, Yanwu Huo, Taotao Wei, Xiaonan Wang, Qian Wang, Haojue Wang, Chengjun Cui, Qifeng Shi, Jing Jiang,Lizeng Gao*. Metastable Iron Sulfides Gram-Dependently Counteract ResistantGardnerella Vaginalisfor Bacterial Vaginosis Treatment.Advanced Science, 2022, 2104341.

6. Xiaoyan Zheng, Yiman Duan, Jing Pang, Xu Feng,Lizeng Gao*, Juxue Li*. Antibacterial effects of nano-decoction iron polysulfide in epididymitis and the systematic evaluation of its toxicity on the reproductive health of male mice.Ecotoxicology and Environmental Safety, 2022, 231: 113184.

7. Qian Wang, Jing Jiang,Lizeng Gao*. Catalytic antimicrobial therapy using nanozymes.Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2021, e1769.

8. Ruofei Zhang, Lei Chen, Qian Liang, Juqun Xi, Hanqing Zhao, Yiliang Jin, Xingfa Gao, Xiyun Yan*,Lizeng Gao*, Kelong Fan*. Unveiling the active sites on ferrihydrite with apparent catalase-like activity for potentiating radiotherapy.Nano Today, 2021, 41: 101317.

9. Hui Wei^#,Lizeng Gao^#, Kelong Fan^#, Juewen Liu, Jiuyang He, Xiaogang Qu, Shaojun Dong, Erkang Wang, Xiyun Yan. Nanozymes: A clear definition with fuzzy edges.Nano Today, 2021, 40: 101269.

10. Juqun Xi, Lanfang An, Yaling Huang, Jian Jiang, Yanqiu Wang, Gen Wei, Zhilong Xu, Lei Fan*,Lizeng Gao*. Ultrasmall FeS2 Nanoparticles-Decorated Carbon Spheres with Laser‐Mediated Ferrous Ion Release for Antibacterial Therapy.Small, 2021, 17 (13): 2005473.

11. Xiangqin Meng, Dandan Li, Lei Chen, Helen He, Qian Wang, Chaoyi Hong, Jiuyang He, Xingfa Gao, Yili Yang, Bing Jiang, Guohui Nie, Xiyun Yan*,Lizeng Gao*, Kelong Fan*. High-performance self-cascade pyrite nanozymes for apoptosis-ferroptosis synergistic tumor therapy.ACS nano, 2021, 15 (3): 5735-5751.

12. Juqun Xi, Ruofei Zhang, Liming Wang, Wei Xu, Qian Liang, Jingyun Li, Jian Jiang, Yili Yang, Xiyun Yan*, Kelong Fan*,Lizeng Gao*. A nanozyme‐based artificial peroxisome ameliorates hyperuricemia and ischemic stroke.Advanced Functional Materials, 2021, 31 (9): 2007130.

13.高利增^#, 梁敏敏^#, 温涛^#, 魏辉, 张宇, 范克龙, 江冰, 曲晓刚, 顾宁, 庞代文, 许海燕*, 阎锡蕴*. 纳米酶标准术语.中国科技术语, 2020, 22 (6): 21-24.

14. Xinyu Shen, Ruonan Ma, Yixin Huang, Lei Chen, Zhuobin Xu, Dandan Li, Xiangqin Meng, Kelong Fan, Juqun Xi, Xiyun Yan, Hyun Koo, Yili Yang, Jing Jiang,Lizeng Gao*. Nano-decocted ferrous polysulfide coordinates ferroptosis-like death in bacteria for anti-infection therapy.Nano Today, 2020, 35: 100981.

15. Qian Liang, Juqun Xi, Xuejiao J Gao, Ruofei Zhang, Yili Yang, Xingfa Gao, Xiyun Yan*,Lizeng Gao*, Kelong Fan*. A metal-free nanozyme-activated prodrug strategy for targeted tumor catalytic therapy.Nano Today, 2020, 35: 100935.

16. Tao Qin, Shang Ma, Xinyu Miao, Yan Tang, Dandan Huangfu, Jinyuan Wang, Jing Jiang, Nuo Xu, Yuncong Yin, Sujuan Chen, Xiufan Liu, Yinyan Yin*, Daxin Peng*,Lizeng Gao*. Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune-Adjuvant.Advanced Science, 2020, 7 (18): 2000771.

17. Ye Yuan, Liping Wang,Lizeng Gao*. Nano-Sized Iron Sulfide: Structure, Synthesis, Properties, and Biomedical Applications.Frontiers in Chemistry, 2020, 8, 10.3389/fchem.2020.00818.

18. Juqun Xi, Gen Wei, Lanfang An, Zhuobin Xu, Zhilong Xu, Lei Fan*,Lizeng Gao*. Copper/carbon hybrid nanozyme: tuning catalytic activity by copper state for antibacterial therapy.Nano Letters, 2019, 19 (11): 7645-7654.

19. Tao Qin^#, Ruonan Ma^#, Yinyan Yin, Xinyu Miao, Sujuan Chen, Kelong Fan, Juqun Xi, Qi Liu, Yunhao Gu, Yuncong Yin, Jiao Hu, Xiufan Liu, Daxin Peng*,Lizeng Gao*. Catalytic inactivation of influenza virus by iron oxide nanozyme.Theranostics, 2019; 9(23): 6920-6935.

20. Shourong Shi*, Shu Wu, Yiru Shen, Shan Zhang, Yunqi Xiao, Xi He, Jiansen Gong, Yuhua Farnell, Yan Tang, Yixin Huang,Lizeng Gao*. Iron oxide nanozyme suppresses intracellular Salmonella Enteritidis growth and alleviates infectionin vivo.Theranostics, 2018; 8(22): 6149-6162.

21. Yunhao Gu, Yixin Huang, Zhiyue Qiu, Zhuobin Xu, Dandan Li, Lei Chen, Jing Jiang,Lizeng Gao*. Vitamin B₂functionalized iron oxide nanozymes for mouth ulcer healing.Science China Life Sciences, 2020, 63 (1): 68-79.

22. Zhuobin Xu, Zhiyue Qiu, Qi Liu, Yixin Huang, Dandan Li, Xinggui Shen, Kelong Fan, Juqun Xi, Yunhao Gu, Yan Tang, Jing Jiang, Jialei Xu, Jinzhi He, Xingfa Gao, Yuan Liu, Hyun Koo, Xiyun Yan andLizeng Gao*. Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections.Nature Communications, 2018, 9: 3713.

23. Kelong Fan, Juqun Xi, Lei Fan, Peixia Wang, Chunhua Zhu, Yan Tang, Xiangdong Xu, Minmin Liang, Bing Jiang, Xiyun Yan*,Lizeng Gao*.In vivoguiding nitrogen-doped carbon nanozyme for tumor catalytic therapy.Nature communications, 2018, 9 (1): 1440.

24. Qiuwen Wu, Gen Wei, Zhuobin Xu, Jing Han, Juqun Xi*, Lei Fan*,Lizeng Gao*. Mechanistic Insight into the Light-Irradiated Carbon Capsules as an Antibacterial Agent.ACS applied materials & interfaces, 2018, 10(30): 25026-25036.

25. Lei Fan, Xiangdong Xu, Chunhua Zhu, Jie Han,Lizeng Gao*, Juqun Xi*, Rong Guo. Tumor Catalytic-Photothermal Therapy with Yolk-Shell Gold@ Carbon Nanozymes.ACS applied materials & interfaces, 2018, 10 (5): 4502-4511.

26. 唐燕, 仇智月, 许卓斌,高利增*. 纳米酶的抗菌机理与应用[J].生物化学与生物物理进展, 2018, 45(2): 118-128.

27.Lizeng Gao*, Kelong Fan, Xiyun Yan*. Iron Oxide Nanozyme: A Multifunctional Enzyme Mimetic for Biomedical Applications.Theranostics, 2017, 7(13): 3207-3227.

28. Kelong Fan, Hui Wang, Juqun Xi, Qi Liu, Xiangqin Meng, Demin Duan,Lizeng Gao*, Xiyun Yan*. Optimization of Fe₃O₄nanozyme activity via single amino acid modification mimicking an enzyme active site.Chemical Communications, 2017, 53 (2), 424-427.

29.Lizeng Gao, Xiyun Yan. Nanozymes: an emerging field bridging nanotechnology and biology.Science China Life Sciences, 2016, 59(4): 400-402.

30.Lizeng Gao*, Yuan Liu, Dongyeop Kim, Yong Li, Geelsu Hwang, Pratap C. Naha, David P. Cormode, Hyun Koo*. Nanocatalysts promote Streptococcus mutans biofilm matrix degradation and enhance bacterial killing to suppress dental caries in vivo.Biomaterials, 2016, 101: 272-284.

31.Lizeng Gao, Jiamin Wu, Di Gao. Enzyme-controlled self-assembly and transformation of nanostructures in a tetramethylbenzidine/horseradish peroxidase/H₂O₂system.ACS Nano, 2011, 5 (8): 6736-6742.

32.Lizeng Gao^#, Jie Zhuang^#, Leng Nie, Jinbin Zhang, Yu Zhang, Ning Gu, Taihong Wang, Jing Feng, Dongling Yang, Sarah Perrett*, Xiyun Yan*. Intrinsic Peroxidase-like Activity of Ferromagnetic Nanoparticles.Nature Nanotechnology, 2007, 2 (9): 577-583.

（资料来源：高利增研究员，2022-04-18）