2003.09 - 2007.06 B.M., Nanjing Agricultural University, Nanjing, China

2007.09 - 2012.09 Ph.D. in Microbiology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China

2012.09 - 2015.12 Assistant Professor, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

2016.01 - Associate Professor, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

My research is focus on structural biology of epigenetic regulation of gene transcription, including nucleosome assembly and remodeling, histone modification and recognition. I mainly studied the structural basis of chromatin remodelers, histone chaperones, and histone modification enzymes in complex with nucleosomes, the recognition of modified histones, and the mechanism of establishment and maintenance of higher chromatin structures.

NSFC Major Research Plan-“Study of regulatory mechanisms and intervention strategies of histone acetylation”, 2019-2022

NSFC Young Scientists Program-“Structure mechanism studies ofoskarmRNA recognition by RNA-binding protein Smaug inDrosophilagerm cell development”, 2015-2017

NSFC General Program-“structural and functional studies of important protein complexes duringDrosophilagerm cell development”, 2014-2017

1. Xiang Xu^#, Mingzhu Wang^#, Jixue Sun^#，Zhenyu Yu^#, Guohong Li, Na Yang*, and Rui-Ming Xu*. Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex.Nucleic Acids Research. 2021; 49(13):7740-7752. (^#co-first author)

2. Na Yang^#*,Zhenyu Yu^#, Meng long Hu^#, Mingzhu Wang, Ruth Lehmann*, Ruiming Xu*. Structure of Drosophila Oskar reveals a novel RNA binding protein.Proc Natl Acad Sci. 2015; 112(37):11541-6. (^#co-first author)

3.Zhenyu Yu, Hong Zhu, Guosong Zheng, Weihong Jiang*, Yinhua Lu*. A genome-wide transcriptomic analysis reveals diverse roles of the two-component system DraR-K in the physiological and morphological differentiation of Streptomyces coelicolor.Applied Microbiology and Biotechnology. 2014; 98(22):9351-63.

4.Zhenyu Yu, Hong Zhu, Fujun Dang, Weiwen Zhang, Zhongjun Qin, Sheng Yang, Huarong Tan, Yinhua Lu*, Weihong Jiang*. Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor.Molecular Microbiology. 2012; 85(3):535-556.

5. Yinhua Lu, Juanmei He, Hong Zhu,Zhenyu Yu, Rui Wang, Fujun Dang, Sheng Yang, Weihong Jiang. An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor.Journal of Bacteriology.2011; 193: 3020-3032.

6. Dan Shu, Lei Chen, Weihua Wang,Zhenyu Yu, Cong Ren, Sheng Yang, Yinhua Lu*, Weihong Jiang*. afsQ1-Q2-sigQ is a pleiotropic but conditionally required signal transduction system for both secondary metabolism and morphological development in Streptomyces coelicolor.Applied Microbiology and Biotechnology.2009; 81: 1149-1160.

(From Zhenyu Yu, December 17, 2021)