2003 - 2007 B.S., Biological Sciences, College of Biological Sciences, China Agricultural University, Beijing, China

2007 - 2012 Ph.D., Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University & National Institute of Biological Sciences, Beijing, China

2012 - 2014 Postdoc, National Institute of Biological Sciences, Beijing, China

2013 - 2015 Institute of Biophysics, CAS Associate Professor

2014 - 2019 Associate Professor, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

1. Analysis of the distribution of histone variant H3.3 containing H3-H4 tetramer splitting events at genomewide level by utilizing gene induction system and sequential purification based ChIP-seq technology.

2. Purification and characterization of histone H3K36me2 methyltransferase Ash1 complex.

1. Hou P^#,Huang C^#, Liu C, Yang N, Yu T, Yin Y, Zhu B, Xu R. Structural insights into stimulation of Ash1’s H3K36 methyltransferase activity by Mrg15 binding.Structure. Published online, 2019 Feb 28.

2.Huang C^#, Yang F^#, Zhang Z^#, Zhang J, Cai G, Li L, Zheng Y, Chen S, Xi R, Zhu B. Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila.Nat Commun2017.8(1):1649.

3.Huang C^#, Zhang Z^#, Xu M, Li Y, Li Z, Ma Y, Cai T, and Zhu B. H3.3-H4 tetramer splitting events feature cell-type specific enhancers.PLoS Genet2013. 9(6): p. e1003558.

4. Yuan W, Xu M,Huang C, Liu N, Chen S, Zhu B. 2011. H3K36 methylation antagonizes PRC2-mediated H3K27 methylation.J Biol Chem286: 7983-7989.

5. Xu M, Long C, Chen X,Huang C, Chen S, Zhu B. 2010. Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly.Science328: 94-98.

Reviews

1.Huang C, Zhu B. Roles of H3K36-specific histone methyltransferases in transcription: antagonizing silencing and safeguarding transcription fidelity.Biophys Rep. 2018;4(4):170-177

2.Huang C, Zhu B. 2014. H3.3 turnover: a mechanism to poise chromatin for transcription, or a response to open chromatin?Bioessays36: 579-584.

3.Huang C, Xu M, Zhu B. 2013. Epigenetic inheritance mediated by histone lysine methylation: maintaining transcriptional states without the precise restoration of marks?Philos Trans R Soc Lond B Biol Sci368: 20110332.

(From Chang Huang, March 25, 2019)