2005.09 - 2009.06 Wuhan University of Science and Technology, Bachelor of Medicine

2009.09 - 2015.12 University of Chinese Academy of Sciences, Ph.D

2016.01 - 2018.12 Institute of Biophysics, CAS Assistant Professor

2019.12 - Institute of Biophysics, CAS Associate Professor

1. Glycoproteins of enveloped virus determine virus entry into host cells and host tropism, which is an important target for therapeutics development. Investigating the structure information of virus glycoprotein in different fusion states, should help to understand the virus entry mechanism and develop effective vaccine and drugs.

2. The host immune system deploys a variety of proteins to defense pathogen invasion. Structural and functional study of these proteins and related protein complexes would help to uncover the mechanism of host immune response and the regulatory role of virus protein to escape the host immune attack.

I. Research articles

1.Cao D^#, Han X^#, Fan X^#, Xu R-M*, and Zhang, X*. Structrual basis for nucleosome-mediated inhibition of cGAS activity.Cell Research, 2020.

2. Fan X^#,Cao D^#*, Kong L, and Zhang X*. Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein.Nature Communications, 2020, 11, 3618.

3. Gao Y^#,Cao D^#, Zhu J, Feng H, Luo X, Liu S, Yan X-X, Zhang X*, and Gao P*. Structural insights into assembly, operation and inhibition of a type I restriction-modification system.Nature Microbiology, 2020, 5, 1107-1118.

4. Pan X^#,Cao D^#, Xie F^#, Xu F^#, Su X, Mi H*, Zhang X*, and Li M*. Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase.Nature Communications, 2020, 11, 610.

5. Cao P^#,Cao D^#, Si L, Su X, Tian L, Chang W, Liu Z, Zhang X*, and Li M*. Structural basis for energy and electron transfer of the photosystem I-IsiA-flavodoxin supercomplex.Nature Plants, 2020, 6, 167-176.

6. Yuan Y^#,Cao D^#, Zhang Y^#, Ma J^#, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y*, Zhang X*, and Gao GF*. Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains.Nature Communications, 2017, 8, 15092.

7.Cao D, Wang M, Qiu X, Liu D, Jiang H, Yang N*, and Xu R-M.* (2015). Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol.Genes & development, 2015, 29, 1316-1325.

II. Invited reviews

1.Cao D^#, Yang N*. (2015) Structure and Catalytic Mechanisms of Histone Deacetylases.Progress in Biochemistry and Biophysics, 2015, 42, 978-93.

(From Duanfang Cao, December 29, 2021)