2004.09 - 2008.06 Bachelor in Biological Sciences, China Agricultural University

2008.09 - 2013.06 Ph.D. in Biology, China Agricultural University, Beijing, China Joint with National Institute of Biological Sciences, Beijing (NIBS)

2013.07 - 2015.05 Postdoc fellow at National Institute of Biological Sciences, Beijing (NIBS)

2015.06 - 2019.09 Postdoc fellow at Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Germany

2019.10 - Associate Professor, Institute of Biophysics, Chinese Academy of Sciences

2013 Excellent oral presentation prize, 3ndChinese C. elegans Meeting, Hefei, China

2013 Monsanto scholarship award for excellent student-research project

2012 Outstanding Student, National Institute of Biological Sciences, Beijing

2011 Excellent Graduate Students of China Agriculture University

Macropinocytosis is a process of large-scale, non-selective fluid uptake. Cells extend thin sheets and cups (circular ruffles) from their plasma membrane into the medium, and eventually close them to entrap a droplet of fluid inside a vesicle called macropinosome. Macropinocytosis is important in a range of physiological processes. It allows cells to sample environment and uptake nutrients or capture antigens. Recent studies have also implicated it in cancer and neurodegenerative diseases. we use Dictyostelium as a model system, combining with high content imaging technique, to screen for novel macropinocytosis regulators. We also utilize mammalian system to further elucidate their function.

1. Zhang Y^#, Tu H^#, Hao Y, Li D, Yang Y, Yuan Y, Guo Z, Li L,Wang H*, Cai H*. (2022) Oligopeptide transporter Slc15A modulates macropinocytosis inDictyosteliumby maintaining intracellular nutrient status.Journal of Cell Science. 135(7):jcs259450. (*corresponding)Highlighted in JCS.

2.Wang H, Loerke D, Bruns C, Müller R, Koch PA, Puchkov D, Schultz C, Haucke V. Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway.J Biol Chem., 2020, 295(4):1091-1104.

3.Wang H^#; Lo, Wen-Ting^#; Haucke, Volker; Phosphoinositide switches in endocytosis and in the endolysosomal system.,Curr Opin Cell Bio., 2019, 59: 50-57.

4. Hu J, Cheng S,Wang H, Li X, Liu S, Wu M, Liu Y, Wang X. Distinct roles of two myosins inC.elegansspermatid differentiation.PloS Biol., 2019, Apr 16;17(4).

5.Wang H^#, Lo WT^#, Zagar A, Gulluni F, Lehmann M, Scapozza L, Haucke V and Vadas O. Autoregulation of class II alpha PI3K activity by its lipid-binding PX-C2 domain module.Mol Cell., 2018, 71(2):343-351.

6. Su Y, Li L,Wang H, Wang X and Zhang Z. All-In-One Azides: Empowered Click Reaction for in vivo Labeling and Imaging of Biomolecules.Chem Commun., 2016, 52(10):2185-8.

7. Cheng S, Wang K, Zou W, Miao R, Huang Y,Wang H, Wang X. PtdIns(4,5) P2 and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance.J Cell Biol., 2015,210(3):485-502.

8.Wang H^#, Lu Q*, Cheng S, Wang X, Zhang H. Autophagy activity contributes to programmed cell death inCaenorhabditis elegans.Autophagy., 2013, (12):1975-82.

9. Zhang Y,Wang Hand Wang X. Quantification of Cell Corpses, Cell Death Occurrence, Cell Corpse Duration.Bio-protocol., 2013, Vol 3, Iss 9.

10. Huang J^#,Wang H^#, Chen Y, Wang X, Zhang H. Residual body removal during spermatogenesis inC. elegansrequires genes that mediate cell corpse clearance.Development., 2012, 139(24): 4613-22.

11. Zhang Y,Wang H, Kage-Nakadai E, Mitani S, Wang X.C. eleganssecreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpseengulfment.Curr Biol., 2012 22(14):1276-84.

(From Haibin Wang, April 27, 2023)