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Jun Xiong
Ph.D., Associate Professor
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Member of the Youth Innovation Promotion Association of CAS National Laboratory of Biomacromolecules, IBP
Research Interests: Epigenetic regulation mechanism of transcription
Email: xiongjun@ibp.ac.cn
Tel: 010-64888213
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Chinese personal homepage
- Biography
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2005.09 - 2009.06 B.S. in Biology, School of Life Sciences, Sun Yat-sen University
2009.09 - 2015.01 Ph.D in Biochemistry and Molecular Biology, Peking Union Medical College&National Institute of Biological Sciences, Beijing
2015.01 - 2019.06 Research assistant, Institute of Biophysics, Chinese Academy of Sciences, Beijing
2019.07 - 2020.12 Assistant Professor, Institute of Biophysics, Chinese Academy of Sciences, Beijing
2021.01 - Associate Professor, Institute of Biophysics, Chinese Academy of Sciences, Beijing
- Awards
- Membership in Academies & Societies
- Research Interests
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Chromatin serves as the template for transcription in mammalian cells, which contributes to the regulation of transcription initiation, elongation, RNA splicing, termination and polyadenylation, etc. We study the molecular mechanisms that underlie these complex processes contributed by important chromatin factors.
- Grants
- Selected Publications
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1. Zhang T, Zhang Z, Dong Q,Xiong J*, Zhu B*. Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells.Genome Biol, 2020. 21(1):45.
2. Wang C, Zhu B*, andXiong J*. Recruitment and reinforcement: maintaining epigenetic silencing.Sci China Life Sci, 2018. 61(5): 515-522.
3.Xiong J, Zhang Z, and Zhu B*. Polycomb "polypacks" the chromatin.Proc Natl Acad Sci U S A, 2016. 113(52): 14878-14880.
4.Xiong J#, Zhang Z#*, Chen J, Huang H, Xu Y, Ding X, Zheng Y, Nishinakamura R, Xu GL, Wang H, Chen S, Gao S, and Zhu B*. Cooperative Action between SALL4A and TET Proteins in Stepwise Oxidation of 5-Methylcytosine.Mol Cell, 2016. 64(5): 913-925.
5. Zhou T,Xiong J, Wang M, Yang N, Wong J, Zhu B, and Xu RM*. Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2.Mol Cell, 2014. 54(5): 879-86.
6. Chen X#,Xiong J#, Xu M, Chen S, and Zhu B*. Symmetrical modification within a nucleosome is not required globally for histone lysine methylation.EMBO Rep, 2011. 12(3): 244-51.
7. Wu H, Chen X,Xiong J, Li Y, Li H, Ding X, Liu S, Chen S, Gao S, and Zhu B*. Histone methyltransferase G9a contributes to H3K27 methylation in vivo.Cell Res, 2011. 21(2): 365-7.
(From Jun Xiong, November 2, 2021)